Peripherally inserted central catheter-related complications in cancer patients: a prospective study of over 50,000 catheter days



To evaluate incidence and risk factors of peripherally inserted central catheter (PICC)-related complications in cancer patients.


A prospective, multicenter, cohort study of cancer patients with PICC insertion was performed from February 1, 2013 to April 24, 2014. All patients were monitored in clinic until PICCs were removed. The primary endpoint was PICC removal due to complications. Patient-, catheter- and insertion-related factors were analyzed in univariable and multivariable logistic regression analysis to identify significant independent risk factors for PICC-related complications.


There were 477 cancer patients included, for a total of 50,841 catheter-days. Eighty-one patients (17.0%) developed PICC-related complications, with an incidence of 1.59 per 1000 catheter days. Thirty-six (7.5%) PICCs were removed because of complications. The most common complications were skin allergy (4.6%), catheter occlusion (3.4%) and accidental withdrawal (2.3%). Nine (1.9%) patients developed symptomatic upper extremity deep venous thrombosis (UEDVT) and central line associated bloodstream infection (CLABSI) was shown in six (1.3%) PICCs with an infection rate 0.12 per 1000 catheter days. In multivariable analysis, body mass index (BMI) >25 (odds ratio, 2.09; 95% confidence interval, 1.26-3.47, p = 0.004) was shown to be a significant risk factor for PICC complications.


Cancer patients with BMI greater than 25 were more likely to have PICC complications.

J Vasc Access 2017; 18(2): 153 - 157




Junren Kang, Wei Chen, Wenyan Sun, Ruibin Ge, Hailong Li, Enling Ma, Qingxia Su, Fang Cheng, Jinhua Hong, Yuanjuan Zhang, Cheng Lei, Xinchuan Wang, Aiyun Jin, Wanli Liu

Article History


Financial support: No grants or funding have been received for this study.
Conflict of interest: None of the authors has financial interest related to this study to disclose.

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  •  Department of Parenteral and Enteral Nutrition, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing - China
  •  Department of Nursing, NanFang Hospital, Southern Medical University, Guangzhou - China
  •  Department of Nursing, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan - China
  •  Department of Nursing, Jiangxi Cancer Hospital, Nanchang - China
  •  Department of Nursing, The Second Affiliated Hospital, ShanXi Medical University, Taiyuan - China
  •  Department of Nursing, First hospital of Shijiazhuang, HeBei Medical University, Shijiazhuang - China
  •  Department of Nursing, XiJing Hospital, Fourth Military Medical University, Xian - China
  •  Department of Nursing, The First Affiliated Hospital, ZheJiang University, Hangzhou - China
  •  Department of Nursing, XiangYa Hospital, Central South University, Changsha - China

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