Arteriovenous fistula maturation in patients with permanent access created prior to or after hemodialysis initiation



Multiple factors and comorbidities have been implicated in the ability of arteriovenous fistulas (AVF) to mature, including vessel anatomy, advanced age, and the presence of coronary artery disease or peripheral vascular disease. However, little is known about the role of uremia on AVF primary failure. In this study, we attempt to evaluate the effect of uremia on AVF maturation by comparing AVF outcomes between pre-dialysis chronic kidney disease (CKD) stage five patients and those who had their AVF created after hemodialysis (HD) initiation.


We included 612 patients who underwent AVF creation between 2003 and 2015 at the University of Miami Hospital and Jackson Memorial Hospital. Effects of uremia on primary failure were evaluated using univariate statistical comparisons and multivariate logistic regression analyses.


Primary failure occurred in 28.1% and 26.3% of patients with an AVF created prior to or after HD initiation, respectively (p = 0.73). The time of HD initiation was not associated with AVF maturation in multivariate logistic regression analysis (p = 0.57). In addition, pre-operative blood urea nitrogen (p = 0.78), estimated glomerular filtration rate (p = 0.66), and serum creatinine levels (p = 0.14) were not associated with AVF primary failure in pre-dialysis patients.


Our results show that clearance of uremia with regular HD treatments prior to AVF creation does not improve the frequency of vascular access maturation.

J Vasc Access 2017; 18(3): 185 - 191





Juan C. Duque, Laisel Martinez, Marwan Tabbara, Denise Dvorquez, Sushil K. Mehandru, Arif Asif, Roberto I. Vazquez-Padron, Loay H. Salman

Article History


Financial support: The National Institutes of Health grant R01-DK-098511 to R.I.V-P and L.H.S supported this study.
Conflict of interest: All authors declare that they have no competing financial interests that might have influenced the present study or the preparation of the manuscript.

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  • Department of Medicine, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida - USA
  • DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida - USA
  • Department of Medicine, Division of Nephrology, Jersey Shore University Medical Center, Hackensack-Meridian Seton Hall School of Medicine, Neptune, New York - USA
  • Division of Nephrology, Albany Medical College, Albany, New York - USA

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